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The Antibio experimentAn experiment was flown on Spacelab to confirm the results of the Cytos 2 experiment on Salyut 7, which found an increase in minimal inhibitory concentration in in-flight cultures, i.e., an increase of antibiotic resistance. The 1 g centrifuge on Biorack was also used to differentiate the effects of cosmic rays and microgravity. The antibiotic sensitivity of bacteria cultivated in vitro during orbital flight was studied. The bacteria was E. coli, the antibiotic was Colistin. An increase of antibiotic resistance is observed. Three explanations are offered: stimulation of bacterial proliferation in space; a relationship between the transport of antibiotics into cells and modifications of cellular envelope permeability; and a combined effect of both phenomena.
Document ID
19880018775
Document Type
Conference Paper
Authors
Lapchine, L. (Centre Hospitalier Univ. Purpan, Toulouse (France), United States)
Moatti, N. (Centre Hospitalier Univ. Rangueil, Toulouse, France)
Richoilley, G. (Centre Hospitalier Univ. Purpan, Toulouse (France), United States)
Templier, J. (Centre Hospitalier Univ. Purpan, Toulouse (France), United States)
Gasset, G. (Centre Hospitalier Univ. Purpan, Toulouse (France), United States)
Tixador, R. (Centre Hospitalier Univ. Purpan Toulouse, France)
Date Acquired
September 5, 2013
Publication Date
February 1, 1988
Publication Information
Publication: ESA, Biorack on Spacelab D1: An Overview of the First Flight of Biorack, an ESA Facility for Life Sciences Research in Microgravity
Subject Category
MATERIALS PROCESSING
Distribution Limits
Public
Copyright
Other