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Interferon effects on protozoan infectionsThe effects of interferon (IFN) on mice infected with two different parasitic protozoans, Trypanosoma cruzi and Trypanosoma brucei rhodesiense, are investigated experimentally. The preparation of the cell cultures, IFN and assays, antibody, and the experimental procedures are described. It is observed that in cells treated with IFN-gamma there is an increased association of T. cruzi with murine macrophages and an increase in the killing of T. cruzi by IFN-gamma-treated murine macrophages. For spleen cells infected with T.b. rhodesiense in vitro, it is detected that live trypanosomes cannot induce IFN in cells from normal mice, but can in cells from immunized mice; and that trypanosome-lysates induce IFN in vitro in cells from normal mice. The data suggest that there is a two-step mechanism for mice against T. cruzi and T.b. rhodesiense.
Document ID
19880023732
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Sonnenfeld, G.
(Louisville, University KY, United States)
Wirth, J.
(Michigan State University East Lansing, United States)
Kierszenbaum, F.
(Louisville Univ. KY, United States)
Degee, A. L. W.
(Louisville Univ. KY, United States)
Mansfield, J. M.
(Wisconsin, University Madison, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1985
Subject Category
Life Sciences (General)
Accession Number
88A10959
Funding Number(s)
CONTRACT_GRANT: NIH-AI-22441
CONTRACT_GRANT: NCC2-213
CONTRACT_GRANT: NIH-AI-17041
CONTRACT_GRANT: NIH-AI-18848
CONTRACT_GRANT: NIH-AI-07203
Distribution Limits
Public
Copyright
Other

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