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Mechanisms of antimotion sickness drugsEight subjects, male and female, were rotated using the step method to progressively increase the speed of rotation (+2 rpm) after every 40 head movements to a maximum of 35 rpm. The end point for motion sickness was the Graybiel Malaise III total of symptoms short of frank nausea. The drug treatments were placebo, scopolamine 0.6 mg and 1 mg, scopolamine 0.6 mg/d-amphetamine 10 mg, scopolamine 1 mg/d-amphetamine 10 mg, and amphetamine 10 mg. Scopolamine increased tolerated head movements over placebo level by + 81; scopolamine 1 mg + 183; d-amphetamine by + 118; scopolamine 0.6/d-amphetamine by + 165; and scopolamine 1 mg/d-amphetamine 10 mg by + 201. The drugs effective in preventing motion sickness are considered to be divided into those with central acetylcholine blocking activity and those which enhance norepinephrine activity. A combination of both of these actions produces the most effective antimotion sickness medications. It is concluded that the balance between the acetylcholine and norepinephrine activity in the CNS appears to be responsible for motion sickness.
Document ID
19880025775
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wood, C. D.
(Louisiana State Univ. Shreveport, LA, United States)
Manno, J. E.
(Louisiana State Univ. Shreveport, LA, United States)
Wood, M. J.
(Louisiana State Univ. Shreveport, LA, United States)
Manno, B. R.
(Louisiana State Univ. Shreveport, LA, United States)
Redetzki, H. M.
(Louisiana State University Shreveport, United States)
Date Acquired
August 13, 2013
Publication Date
September 1, 1987
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 58
ISSN: 0095-6562
Subject Category
Aerospace Medicine
Accession Number
88A13002
Funding Number(s)
CONTRACT_GRANT: NAS9-16801
Distribution Limits
Public
Copyright
Other

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