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Effect of anabolic steroids on overloaded and overloaded suspended skeletal muscleThe effect of treatment with an anabolic steroid (nandrolone decanoate) on the muscle mass, the subcellular protein content, and the myosin patterns of normal overloaded and suspended overloaded plantaris muscle in female rat was investigated, dividing rats into six groups: normal control (NC), overload (OV), OV steroid (OV-S), normal suspended (N-sus), OV suspended (OV-sus), and OV suspended steroid (OV-sus-S). Relative to control values, overload produced a sparing effect on the muscle weight of the OV-sus group as well as increases of muscle weight of the OV group; increased protein content; and an increased expression of slow myosin in both OV and OV-sus groups. Steroid treatment of OV animals did not after the response of any parameter analyzed for the OV group, but in the OV-sus group steroid treatment induced increases in muscle weight and in protein content of the OV-sus-S group. The treatment did not alter the pattern of isomyosin expression observed in the OV or the OV-sus groups. These result suggest that the steroid acts synergistically with functional overload only under conditions in which the effect of overload is minimized by suspension.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Tsika, R. W.
(California Univ. Irvine, CA, United States)
Herrick, R. E.
(California Univ. Irvine, CA, United States)
Baldwin, K. M.
(California, University Irvine, United States)
Date Acquired
August 13, 2013
Publication Date
November 1, 1987
Publication Information
Publication: Journal of Applied Physiology
Volume: 63
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
Funding Number(s)
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