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Brain cholinergic involvement during the rapid development of tolerance to morphineThe effect of repeated administration of morphine on the activities of the cholinergic enzymes, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE), in specific brain regions were studied in rats treated with 10 mg/kg morphine for one or two days. Repeated administration of morphine was associated with a decline in the degree of analgesia produced and with a significant increase of AChE activity of the medulla oblongata. A single injection of morphine resulted in a significant decline in ChAT activity in the hypothalamus, cerebellum, and medulla oblongata regions. After two consecutive injections, no decline in ChAT was observed in these regions, while in the cerebral cortex the second administration elicited a significant decline. The results suggest that the development of tolerance to morphine may be mediated through changes in ChAT activity and lend support to the involvement of the central cholinergic system in narcotic tolerance.
Document ID
19880033045
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wahba, Z. Z.
(Florida Agricultural and Mechanical Univ. Tallahassee, FL, United States)
Oriaku, E. T.
(Florida Agricultural and Mechanical Univ. Tallahassee, FL, United States)
Soliman, S. F. A.
(Florida Agricultural and Mechanical University Tallahassee, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1987
Publication Information
Publication: Pharmacology
Volume: 34
ISSN: 0031-7012
Subject Category
Life Sciences (General)
Accession Number
88A20272
Funding Number(s)
CONTRACT_GRANT: NSG-2183
Distribution Limits
Public
Copyright
Other

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