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Effect of antiorthostatic suspension on interferon-alpha/beta production by the mouse (41939)Mice were suspended in a model that simulates the weightlessness that occurs during prolonged space flight. After one and two weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta. Interferon production was severely reduced in mice that had been suspended. When mice were allowed to recover in cages for a week following removal from suspension, they recovered their full interferon-production capacity. Mice suspended in an orthostatic (horizontal) position did not have their interferon production capabilities affected, which indicates that stress per se was not a major component in the effects of antiorthostatic suspension on interferon induction.
Document ID
19880033084
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Rose, Andrea
(Louisville Univ. KY, United States)
Steffen, Joseph M.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville Univ. KY, United States)
Sonnenfeld, Gerald
(Louisville, University KY, United States)
Mandel, Adrian D.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1984
Publication Information
Publication: Society for Experimental Biology and Medicine, Proceedings
Volume: 177
ISSN: 0037-9727
Subject Category
Life Sciences (General)
Accession Number
88A20311
Funding Number(s)
CONTRACT_GRANT: NCC2-213
CONTRACT_GRANT: NSG-2325
Distribution Limits
Public
Copyright
Other

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