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The effect of altered 5-hydroxytryptamine levels on beta-endorphinThe purpose of the present study was to examine the effect of altering the concentration of 5-hydroxytryptamine (5-HT) on beta-endorphin (beta-Ep) content in the hypothalamus, thalamus, and periaqueductal gray (PAG)-rostral pons regions of the rat brain. The selective 5-HT reuptake inhibitor, fluoxetine (10 mg/kg), significantly lowered beta-Ep content in the hypothalamus and the PAG. Parachlorophenylalanine, which inhibits 5-HT synthesis, significantly elevated beta-Ep in all brain parts studied. Intracisternal injections of the neurotoxin 5-prime, 7-prime-dihydroxytryptamine with desmethylimipramine pretreatment significantly increased beta-Ep content in the hypothalamus and the PAG. In adrenalectomized rats, fluoxetine significantly decreased beta-Ep levels in the hypothalamus and increased the levels in the PAG. The results indicate that 5-HT may modulate the levels of brain beta-Ep.
Document ID
19880033085
Document Type
Reprint (Version printed in journal)
Authors
Soliman, Karam F. A. (Florida Agricultural and Mechanical Univ. Tallahassee, FL, United States)
Mash, Deborah C. (Florida Agricultural and Mechanical Univ. Tallahassee, FL, United States)
Walker, Charles A. (Florida Agricultural and Mechanical University Tallahassee, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1986
Publication Information
Publication: Society for Experimental Biology and Medicine, Proceedings
Volume: 182
ISSN: 0037-9727
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-RR-0811
CONTRACT_GRANT: NIH-R03-AG-03755
CONTRACT_GRANT: NSG-2183
Distribution Limits
Public
Copyright
Other