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Lack of effects of astemizole on vestibular ocular reflex, motion sickness, and cognitive performance in manAstemizole was orally administered to 20 subjects in a randomized, double-blind design to assess the efficacy of this peripherally active antihistamine as an antimotion sickness drug possessing no central side-effects. Measures of vestibular ocular reflex (VOR) were made to evaluate the agent as a selective vestibular depressant. Following one week of orally administered astemizole (30 mg daily), a Staircase Profile Test, a VOR test, and a variety of tests of cognitive performance were administered. These tests revealed no statistically significant effects of astemizole. This leads to the conclusion that, although the drug probably reaches the peripheral vestibular apparatus in man by crossing the blood-vestibular barrier, a selective peripheral antihistamine (H1) action is inadequate to control motion sickness induced through cross-coupled accelerative semicircular canal stimulation in a rotating chair.
Document ID
Document Type
Reprint (Version printed in journal)
Kohl, Randall L. (Universities Space Research Association Houston, TX, United States)
Homick, Jerry L. (Space Biomedical Research Institute Houston, TX, United States)
Cintron, Nitza (Technology, Inc. Hoston, TX, United States)
Calkins, Dick S. (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 13, 2013
Publication Date
December 1, 1987
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 58
ISSN: 0095-6562
Subject Category
Distribution Limits