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Enhancement of viral pathogenesis in mice maintained in an antiorthostatic suspension model - Coordination with effects on interferon productionBoth rodents and men returning from spaceflight have exhibited alterations in immune responses and, in particular, interferon production. This work utilizes a model for antiorthostatic (20-deg head-down tilt), hypokinetic, hypodynamic suspension of mice that simulates some aspects of weightlessness. Female Swiss/Webster mice that are normally resistant to infection with the D variant of encephalomyocarditis virus showed a marked increase in susceptibility to infection when suspended. This correlated with a drop in interferom production. Control, orthostatically suspended mice (no tilt) showed no increase in susceptibility to the virus.
Document ID
19880041472
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gould, C. L.
(Community Blood Center Dayton, OH, United States)
Sonnenfeld, G.
(Louisville, University KY, United States)
Date Acquired
August 13, 2013
Publication Date
January 1, 1987
Publication Information
Publication: Journal of Biological Regulators and Homeostatic Agents
Volume: 1
Issue: 1 19
ISSN: 0393-974X
Subject Category
Life Sciences (General)
Accession Number
88A28699
Funding Number(s)
CONTRACT_GRANT: NCC2-213
Distribution Limits
Public
Copyright
Other

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