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Glucose uptake in rat soleus - Effect of acute unloading and subsequent reloadingThe effect of acutely reduced weight bearing (unloading) on the in vitro uptake of 2-1,2-H-3-deoxy-D-glucose was studied in the soleus muscle by tail casting and suspending rats. After just 4 h, the uptake of 2-deoxy-D-glucose fell (-19 percent) and declined further after an additional 20 h of unloading. This diminution at 24 h was associated with slower oxidation of C-14-glucose and incorporation of C-14-glucose into glycogen. At 3 days of unloading, basal uptake of 2-deoxy-D-glucose did not differ from control. Reloading of the soleus after 1 or 3 days of unloading increased uptake of 2-deoxy-D-glucose above control and returned it to normal within 6 h and 4 days, respectively. These effects of unloading and recovery were caused by local changes in the soleus, because the extensor digitorum longus from the same hindlimbs did not display any alterations in uptake of 2-deoxy-D-glucose or metabolism of glucose.
Document ID
Document Type
Reprint (Version printed in journal)
Henriksen, Eric J.
(Arizona Univ. Tucson, AZ, United States)
Tischler, Marc E.
(Arizona, University Tucson, United States)
Date Acquired
August 13, 2013
Publication Date
April 1, 1988
Publication Information
Publication: Journal of Applied Physiology
Volume: 64
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
Funding Number(s)
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