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the endocrine system in space flightA trial natriuretic factor (ANF), a hormone recently shown to regulate sodium and water excretion, has been measured in blood specimens obtained during flight. After 30 or 42 h of weightlessness, mean ANF was elevated. After 175 or 180 h, ANF has increased by 59 percent, and it changed little between that time and soon after landing. There is probably an increase in ANF early inflight associated with the fluid shift, followed by a compensatory decrease in blood volume. Increased renal blood flow may cause the later ANF decrease. Erythropoietin (Ep), a hormone involved in the control of red blood cell proudction, was measured in blood samples taken during the first Spacelab mission and was significantly decreased on the second day of flight, suggesting also an increase in renal blood flow. Spacelab-2 investigators report that the active vitamin D metabolite 1 alpha, 25-dihydroxyvitamin D-3 increased early in the flight, indicating that a stimulus for increased bone resorption occurs by 30 h after launch.
Document ID
19880046320
Document Type
Reprint (Version printed in journal)
Authors
Leach, C. S.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Johnson, P. C.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Cintron, N. M.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 13, 2013
Publication Date
February 1, 1988
Publication Information
Publication: Acta Astronautica
Volume: 17
ISSN: 0094-5765
Subject Category
AEROSPACE MEDICINE
Report/Patent Number
IAF PAPER 86-382
Distribution Limits
Public
Copyright
Other