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Effects of scopolamine and dextroamphetamine on human performanceThe effects of two drugs used to prevent symptoms of motion sickness in the operational environment were examined in this study of human performance as measured by computer-based tests of cognitive and psychomotor skills. Each subject was exposed repetitively to five tests: symbol-digit substitution, simple reaction time, pattern recognition, digit span memory, and pattern memory. Although there have been previous reports of decreases in human performance in similar testing with higher dosages of scopolamine or dextroamphetamine, no significant decrements were observed with the operational-level combined dose used in this study (0.4 mg oral scopolamine and 5.0 mg oral dextroamphetamine.) The controversy over the use of combination drug therapy in this environnment is discussed along with the indications for further research based on the findings.
Document ID
Document Type
Reprint (Version printed in journal)
Schmedtje, John F., Jr.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Oman, Charles M.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Letz, Richard
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Baker, Edward L.
(MIT, Cambridge; Harvard University Boston, MA, United States)
Date Acquired
August 13, 2013
Publication Date
May 1, 1988
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 59
ISSN: 0095-6562
Subject Category
Behavioral Sciences
Accession Number
Funding Number(s)
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