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Adaptation of bone and tendon to prolonged hindlimb suspension in ratsThe effect of a sustained deprivation of ground reaction forces on mineralized and soft connective tissues was investigated in rats subjected to 28-d-long hind-limb suspension. The results of morphological and biochemical studies carried out on femurs and patellar tendons obtained from suspended and nonsuspended 110-d-old rats showed that prolonged suspension led to an increase of the minimum diameter of the femur middiaphysis (by 12 percent), without any significant alterations in cortical area, density, mineral and collagen concentrations, femur wet weight, length, and DNA and uronic acid concentrations. However, in the patellar tendons of suspended rats, the collagen and proteoglycan concentrations were 28 percent lower than in tendons obtained from nonsuspended animals. These results suggest that ground reaction forces are important for the maintenance of cortical bone and patellar tendon homeostasis during weight-bearing conditions.
Document ID
19880060098
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Vailas, Arthur C.
(California Univ. Los Angeles, CA, United States)
Deluna, Diane M.
(California Univ. Los Angeles, CA, United States)
Lewis, Lisa L.
(California Univ. Los Angeles, CA, United States)
Curwin, Sandra L.
(California Univ. Los Angeles, CA, United States)
Roy, Roland R.
(California, University Los Angeles, United States)
Date Acquired
August 13, 2013
Publication Date
July 1, 1988
Publication Information
Publication: Journal of Applied Physiology
Volume: 65
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
88A47325
Funding Number(s)
CONTRACT_GRANT: NCA2-IR-390-502
CONTRACT_GRANT: NCA2-IR-390-501
Distribution Limits
Public
Copyright
Other

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