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Changes in plasma volume during bed rest - Effects of menstrual cycle and estrogen administrationThe effect of increased blood estrogen concentration, caused either during normal menstrual cycles or by exogenous administration of premarin, on the bed-rest (BR) induced decrease in plasma volume (PV) was investigated. In women who underwent duplicate 11-day BR without estrogen supplementation, the PV was found to decrease significantly, during the first 5 days of BR, to a lower level at which it remained for the rest of the BR period. In women who began BR in the periovulatory stage of the menstrual cycle, the loss of PV was delayed, while women who began BR during other stages of the cycle exhibited the usual trend of the PV decrease during the BR. In women who underwent a single 12-day BR period while taking premarin (1.25 mg/day), PV was found to decrease during the first 4-5 days of BR, but then returned toward the pre-BR level during the remainder of the BR, indicating that estrogens have a role in stabilizing body fluid volume.
Document ID
19880062524
Document Type
Reprint (Version printed in journal)
Authors
Fortney, S. M. (Johns Hopkins Univ. Baltimore, MD, United States)
Beckett, W. S. (Johns Hopkins Univ. Baltimore, MD, United States)
Carpenter, A. J. (Johns Hopkins Univ. Baltimore, MD, United States)
Davis, J. (Johns Hopkins Univ. Baltimore, MD, United States)
Drew, H. (Johns Hopkins University Baltimore, MD, United States)
Date Acquired
August 13, 2013
Publication Date
August 1, 1988
Publication Information
Publication: Journal of Applied Physiology
Volume: 65
ISSN: 0161-7567
Subject Category
AEROSPACE MEDICINE
Funding Number(s)
CONTRACT_GRANT: NAS9-16703
CONTRACT_GRANT: NAS9-17199
Distribution Limits
Public
Copyright
Other