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Record Details

Record 84 of 3069
Diet and the role of lipoproteins, lipases, and thyroid hormones in coronary lesion growth
Author and Affiliation:
Barth, Jacques D.(California Institute of Technology, Jet Propulsion Laboratory, Pasadena, Saint Radboud University)
Jansen, Hans(Jet Propulsion Lab., California Inst. of Tech., Pasadena, CA, United States)
Reiber, Johan H. C.(Jet Propulsion Lab., California Inst. of Tech., Pasadena, CA, United States)
Birkenhager, Jan C.(Rotterdam, Erasmus Universiteit, Netherlands)
Kromhout, Daan(Leiden, Rijksuniversiteit, Netherlands)
et al.
Abstract: The relationships between the coronary lesion growth and the blood contents of lipoprotein fractions, thyroic hormones, and the lipoprotein lipase activity were investigated in male patients with severe coronary atherosclerosis, who participated in a lipid-lowering dietary intervention program. A quantitative computer-assisted image-processing technique was used to assess the severity of coronary obstructions at the beginning of the program and at its termination two years later. Based on absolute coronary scores, patients were divided into a no-lesion growth group (14 patients) and a progression group (21 paients). At the end of the trial, the very-low-density lipoprotein cholesterol and triglycerides were found to be significantly higher, while the high-density lipoprotein cholesterol and hepatic lipase (HL) were lower in the progression group. Multivariate regression analysis showed HL to be the most important determinant of changes in coronary atherosclerotic lesions.
Publication Date: Jan 01, 1987
Document ID:
19890027152
(Acquired Nov 28, 1995)
Accession Number: 89A14523
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of Cardiovascular Pharmacology Supplement; (ISSN 0160-2446); 10; 9, 19
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: Jet Propulsion Lab., California Inst. of Tech.; Pasadena, CA, United States
Erasmus Univ.; Rotterdam, Netherlands
Leiden Univ.; Rotterdam, Netherlands
Saint Radboud Univ. Hospital; Nijmegen, Netherlands
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CORONARY ARTERY DISEASE; DIETS; LIPID METABOLISM; LIPOPROTEINS; BLOOD PLASMA; ENZYMES; LESIONS; REGRESSION ANALYSIS; THYROID GLAND
Imprint And Other Notes: Journal of Cardiovascular Pharmacology Supplement (ISSN 0160-2446), vol. 10, no. 9, 1987, p. S42-S46.
Availability Source: Other Sources
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