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Inhibition of intracellular proteolysis in muscle cultures by multiplication-stimulating activityThe effects of the insulin-like growth factor, multiplication-stimulating activity (MSA), on chick myotube cultures are studied. The results indicate that MSA is an effective anabolic agent regulating protein metabolism and amino acid uptake, but not sugar transport. Similar size effects on protein metabolism and amino acid uptake in serum-free media were observed in parallel studies with insulin, although insulin levels well in excess of the normal physiological range are required to produce significant effects. It is suggested that there is a generally low insulin sensitivity in cultured chick myotubes relative to adult tissues.
Document ID
19890029159
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Janeczko, Richard A.
(State Univ. of New York Brooklyn, NY, United States)
Etlinger, Joseph D.
(New York, State University Brooklyn, United States)
Date Acquired
August 14, 2013
Publication Date
May 25, 1984
Publication Information
Publication: Journal of Biological Chemistry
Volume: 259
ISSN: 0021-9258
Subject Category
Life Sciences (General)
Accession Number
89A16530
Funding Number(s)
CONTRACT_GRANT: NIH-5-R01-HL-21970
CONTRACT_GRANT: NAG2-162
Distribution Limits
Public
Copyright
Other

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