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Regulation of myofibrillar accumulation in chick muscle cultures - Evidence for the involvement of calcium and lysosomes in non-uniform turnover of contractile proteinsThe effects of calcium on the synthesis and the degradation of individual myofibrillar proteins were investigated using primary chick-leg skeletal muscle cultures labeled with S-35-methionine (for protein accumulation experiments) or Ca(2+)-45 (for calcium efflux experiments). It was found that the turnover of individual contractile proteins is regulated nonuniformly by a calcium-dependent mechanism involving lysosomes. The results also indicate that contractile proteins are released from the myofibril before their breakdown to amino acids.
Document ID
19890031366
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Silver, Geri (State Univ. of New York Brooklyn, NY, United States)
Etlinger, Joseph D. (New York, State University, Downstate Medical Center Brooklyn, United States)
Date Acquired
August 14, 2013
Publication Date
December 1, 1985
Publication Information
Publication: Journal of Cell Biology
Volume: 101
ISSN: 0021-9525
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-HL-31494
Distribution Limits
Public
Copyright
Other