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Slow to fast alterations in skeletal muscle fibers caused by clenbuterol, a beta(2)-receptor agonistThe effects of a beta(2)-receptor agonist, clenbuterol, and a beta(2) antagonist, butoxamine, on the skeletal muscle fibers of rats were investigated. It was found that chronic treatment of rats with clenbuterol caused hypertrophy of histochemically identified fast-twitch, but not slow-twitch, fibers within the soleus, while in the extensor digitorum longus the mean areas of both fiber types were increased; in both muscles, the ratio of the number of fast-twitch to slow-twitch fibers was increased. In contrast, a treatment with butoxamine caused a reduction of the fast-twitch fiber size in both muscles, and the ratio of the fast-twitch to slow-twitch fibers was decreased.
Document ID
19890032459
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Zeman, Richard J.
(State Univ. of New York Brooklyn, NY, United States)
Ludemann, Robert
(State Univ. of New York Brooklyn, NY, United States)
Easton, Thomas G.
(State Univ. of New York Brooklyn, NY, United States)
Etlinger, Joseph D.
(New York, State University Brooklyn, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1988
Publication Information
Publication: American Journal of Physiology: Endocrinology and Metabolism
ISSN: 0193-1849
Subject Category
Life Sciences (General)
Accession Number
89A19830
Funding Number(s)
CONTRACT_GRANT: NIH-AR-37145
CONTRACT_GRANT: NAG2-162
Distribution Limits
Public
Copyright
Other

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