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Exercise effects on the size and metabolic properties of soleus fibers in hindlimb-suspended ratsThe effects of four-week-long hind-limb suspension (HS) of rats on the size the soleus muscle fibers and the activity of succinate dehydrogenase (SDH) in dark and light ATPase fibers were investigated together with the efficacy of an endurance exercise (EX) program (daily treadmill exercise for 1.5 h/day at 20 m/min and a 30-percent grade) in ameliorating HS-induced changes. It was found that, in comparison to age-matched controls, the soleus wet weight decreased by 69 and 30 percent in HS and HS-EX rats, respectively, and the percent of dark ATPase fibers increased from 10 percent in controls to 19 and 17 percent, respectively. The values of the integrated fiber activity (activity/min times muscle area) showed a net loss of SDH in both the light and dark ATPase fibers of HS rats, but only in the light ATPase fibers of the HS-EX rats, indicating that exercise ameliorated but did not prevent the muscle fiber atrophy induced by HS.
Document ID
19890044972
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Graham, Scot C.
(California Univ. Los Angeles, CA, United States)
Roy, Roland R.
(California Univ. Los Angeles, CA, United States)
West, Steve P.
(California Univ. Los Angeles, CA, United States)
Thomason, Don
(California Univ. Los Angeles, CA, United States)
Baldwin, Kenneth M.
(California, University Los Angeles and Irvine, United States)
Date Acquired
August 14, 2013
Publication Date
March 1, 1989
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 60
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
89A32343
Funding Number(s)
CONTRACT_GRANT: NIH-NS-16333
CONTRACT_GRANT: NCA2-IR-390-502
Distribution Limits
Public
Copyright
Other

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