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Glycogen supercompensation in rat soleus muscle during recovery from nonweight bearingEvents leading to the normalization of the glycogen metabolism in the soleus muscle of rat, altered by 72-h three days of hind-limb suspension, were investigated during the 72-h recovery period when the animals were allowed to bear weight on all four limbs. Relative importance of the factors affecting glycogen metabolism in skeletal muscle during the recovery period was also examined. Glycogen concentration was found to decrease within 15 min and up to 2 h of recovery, while muscle glucose 6-phosphate, and the fractional activities of glycogen phosphorylase and glycogen synthase increased. From 2 to 4 h, when the glycogen synthase activity remained elevated and the phosphorylase activity declined, glycogen concentration increased, until it reached maximum values at about 24 h, after which it started to decrease, reaching control values by 72 h. At 12 and 24 h, the inverse relationship between glycogen concentration and the synthase activity ratio was lost, indicating that the reloading transiently uncoupled glycogen control of this enzyme.
Document ID
19890057007
Document Type
Reprint (Version printed in journal)
Authors
Henriksen, Erik J. (Arizona Univ. Tucson, AZ, United States)
Kirby, Christopher R. (Arizona Univ. Tucson, AZ, United States)
Tischler, Marc E. (Arizona, University Tucson, United States)
Date Acquired
August 14, 2013
Publication Date
June 1, 1989
Publication Information
Publication: Journal of Applied Physiology
Volume: 66
ISSN: 0161-7567
Subject Category
AEROSPACE MEDICINE
Funding Number(s)
CONTRACT_GRANT: NAG2-384
CONTRACT_GRANT: NIH-RR-05675
Distribution Limits
Public
Copyright
Other