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Mineral catalysis of the formation of the phosphodiester bond in aqueous solution - The possible role of montmorillonite claysThe possible role of montmorillonite clays in the spontaneous formation on the primitive earth of the phosphodiester bond in the presence of water was investigated in experiments measuring the binding of various nucleosides and nucleotides with Na(+)-montmorillonite 22A and the reactions of these compounds with a water-soluble carbodiimide. It was found that, at neutral pH, adenine derivatives bind stronger than the corresponding uracil derivatives, consistent with the protonation of the adenine by the acidic clay surface and a cationic binding of the protonated ring to the anionic clay surface. The reaction of the 5-prime-AMP with carbodiimide resulted in the formation of 2-prime,5-prime-pApA (18.9 percent), 3-prime,5-prime-pApA (11 percent), and AppA (4.8 percent). The yields of these oligomers obtained when poly(U) was used in place of the clay were 15.5 percent, 3.7 percent, and 14.9 percent AppA, respectively.
Document ID
19890064139
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ferris, James P.
(Rensselaer Polytechnic Inst. Troy, NY, United States)
Ertem, Gozen
(Rensselaer Polytechnic Inst. Troy, NY, United States)
KAMALUDDIN
(Rensselaer Polytechnic Inst. Troy, NY, United States)
Agarwal, Vipin
(Rensselaer Polytechnic Inst. Troy, NY, United States)
Hua, Lu Lin
(Rensselaer Polytechnic Institute, Troy, NY, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Planetary Biology and Origins of Life, 20th, 21st, and 23rd, Espoo, Finland, July 18-29, 1988) Advances in Space Research
ISSN: 0273-1177
Subject Category
Space Biology
Accession Number
89A51510
Funding Number(s)
CONTRACT_GRANT: NSF CHE-85-06377
CONTRACT_GRANT: NGR-33-018-148
Distribution Limits
Public
Copyright
Other

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