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neoplastic cell transformation by high-let radiation - molecular mechanismsQuantitative data were collected on dose-response curves of cultured mouse-embryo cells (C3H10T1/2) irradiated with heavy ions of various charges and energies. Results suggests that two breaks formed on DNA within 80 A may cause cell transformation and that two DNA breaks formed within 20 A may be lethal. From results of experiments with restriction enzymes which produce DNA damages at specific sites, it was found that DNA double strand breaks are important primary lesions for radiogenic cell transformation and that blunt-ended double-strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship for high-LET radiation is similar to that for HGPRT locus mutation, chromosomal deletion, and cell transformation, indicating that common lesions may be involved in these radiation effects.
Document ID
19890066845
Document Type
Reprint (Version printed in journal)
Authors
Yang, Tracy Chui-Hsu
(California Univ. Berkeley, CA, United States)
Craise, Laurie M.
(California Univ. Berkeley, CA, United States)
Tobias, Cornelius A.
(California, University Berkeley, United States)
Mei, Man-Tong
(South China Agricultural University Guangzhou, People's Republic of China, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1989
Publication Information
Publication: - Radiation Biology, Espoo, Finland, July 18-29, 1988) Advances in Space Research
ISSN: 0273-1177
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NIH-CA-15184
CONTRACT_GRANT: NASA ORDER T-7163-B
CONTRACT_GRANT: DE-AC03-76SF-00098
Distribution Limits
Public
Copyright
Other