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Protein crystal growth in microgravityMajor advances have been made in several of the experimental aspects of protein crystallography, leaving protein crystallization as one of the few remaining bottlenecks. As a result, it has become important that the science of protein crystal growth is better understood and that improved methods for protein crystallization are developed. Preliminary experiments with both small molecules and proteins indicate that microgravity may beneficially affect crystal growth. For this reason, a series of protein crystal growth experiments using the Space Shuttle was initiated. The preliminary space experiments were used to evolve prototype hardware that will form the basis for a more advanced system that can be used to evaluate effects of gravity on protein crystal growth. Various optical techniques are being utilized to monitor the crystal growth process from the incipient or nucleation stage and throughout the growth phase. The eventual goal of these studies is to develop a system which utilizes optical monitoring for dynamic control of the crystallization process.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Rosenblum, William M.
(Alabama Univ. Birmingham., United States)
Delucas, Lawrence J.
(Alabama Univ. Birmingham., United States)
Wilson, William W.
(Mississippi State Univ. Mississippi State., United States)
Date Acquired
August 14, 2013
Publication Date
August 1, 1989
Publication Information
Publication: NASA, Lewis Research Center, NASA Laser Light Scattering Advanced Technology Development Workshop, 1988
Subject Category
Materials Processing
Accession Number
Distribution Limits
Work of the US Gov. Public Use Permitted.
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