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Record Details

Record 40 of 279
Protein crystal growth in microgravity
Offline Availability: Go to Request Form
Author and Affiliation:
Rosenblum, William M.(Alabama Univ., Birmingham., United States)
Delucas, Lawrence J.(Alabama Univ., Birmingham., United States)
Wilson, William W.(Mississippi State Univ., Mississippi State., United States)
Abstract: Major advances have been made in several of the experimental aspects of protein crystallography, leaving protein crystallization as one of the few remaining bottlenecks. As a result, it has become important that the science of protein crystal growth is better understood and that improved methods for protein crystallization are developed. Preliminary experiments with both small molecules and proteins indicate that microgravity may beneficially affect crystal growth. For this reason, a series of protein crystal growth experiments using the Space Shuttle was initiated. The preliminary space experiments were used to evolve prototype hardware that will form the basis for a more advanced system that can be used to evaluate effects of gravity on protein crystal growth. Various optical techniques are being utilized to monitor the crystal growth process from the incipient or nucleation stage and throughout the growth phase. The eventual goal of these studies is to develop a system which utilizes optical monitoring for dynamic control of the crystallization process.
Publication Date: Aug 01, 1989
Document ID:
19900007786
(Acquired Nov 06, 1995)
Accession Number: 90N17102
Subject Category: MATERIALS PROCESSING
Document Type: Conference Paper
Publication Information: NASA, Lewis Research Center, NASA Laser Light Scattering Advanced Technology Development Workshop, 1988; p 235-256
Publisher Information: United States
Financial Sponsor: NASA; United States
Organization Source: Alabama Univ.; Dept. of Physiological Optics and Optometry.; Birmingham, AL, United States
Description: 22p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: CRYSTALLIZATION; GRAVITATIONAL EFFECTS; MICROGRAVITY; MOLECULAR STRUCTURE; PROTEIN CRYSTAL GROWTH; BIOPROCESSING; CRYSTALLOGRAPHY; LASER BEAMS; LIGHT SCATTERING; NUCLEATION; NUCLEIC ACIDS; SPACE COMMERCIALIZATION; SPACE PROCESSING; SPACEBORNE EXPERIMENTS
Imprint And Other Notes: In NASA, Lewis Research Center, NASA Laser Light Scattering Advanced Technology Development Workshop, 1988 p 235-256 (SEE N90-17085 09-35)
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