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8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazineVomiting was suppressed in cats pretreated with 8-OH-DPAT and then challenged with an emetic stimulus; motion, xylazine or cisplatin. The antiemetic effect is likely due to stimulation of postsynaptic serotonin-1A receptors. The most parsimonious explanation is that it acts at a convergent structure, presumably at or near the vomiting center. If so, 8-OH-DPAT may block emesis elicited by virtually any other stimulus. A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis. These results do not support the possibility that the antiemetic effects of 8-OH-DPAT were the result of anxiolytic activity.
Document ID
19900029231
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lucot, James B.
(Wright State Univ. Dayton, OH, United States)
Crampton, George H.
(Wright State University Dayton, OH, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Pharmacology, Biochemistry and Behavior
Volume: 33
Issue: 3 19
ISSN: 0091-3057
Subject Category
Life Sciences (General)
Accession Number
90A16286
Funding Number(s)
CONTRACT_GRANT: NCC2-229
Distribution Limits
Public
Copyright
Other

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