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Metabolism of branched-chain amino acids in leg muscles from tail-cast suspended intact and adrenalectomized ratsThe effects of muscle unloading, adrenalectomy, and cortisol treatment on the metabolism of branched-chain amino acids in the soleus and extensor digitorum longus of tail-cast suspended rats were investigated using C-14-labeled lucine, isoleucine, and valine in incubation studies. It was found that, compared to not suspended controls, the degradation of branched-chain amino acids in hind limb muscles was accelerated in tail-cast suspended rats. Adrenalectomy was found to abolish the aminotransferase flux and to diminish the dehydrogenase flux in the soleus. The data also suggest that cortisol treatment increases the rate of metabolism of branched-chain amino acids at the dehydrogenase step.
Document ID
19900034855
Document Type
Reprint (Version printed in journal)
Authors
Jaspers, Stephen R. (Arizona Univ. Tucson, AZ, United States)
Henriksen, Erik (Arizona Univ. Tucson, AZ, United States)
Jacob, Stephan (Arizona Univ. Tucson, AZ, United States)
Tischler, Marc E. (Arizona, University Tucson, United States)
Date Acquired
August 14, 2013
Publication Date
February 1, 1989
Publication Information
Publication: Metabolism
Volume: 38
ISSN: 0026-0495
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NAGW-227
CONTRACT_GRANT: NAG2-384
Distribution Limits
Public
Copyright
Other