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Bone growth and calcium balance during simulated weightlessness in the ratRats, age 28 days, experiencing tail suspension in modified metabolic cages for 1, 2, and 3 wk were compared with littermate controls. Food and water consumption, urinary and fecal Ca excretion, and serum Ca were measured; hearts, fore- and hindlimb bones, skulls, and mandibles were removed for determination of wet, dry, and ash weights and Ca concentration and for histological examination. Weight gain and Ca intake and excretion were the same for both groups; both displayed net Ca gain. Suspended rats had significantly lower wet, dry, and ash weights of femora and tibiae. Dry weights of the humeri and radii/ulnae were moderately higher, and the skull and mandible dry and ash weights were significantly higher in suspended than in control rats. Cortical thickness of the femur, but not humerus, was less in suspended rats. The data are consistent with the hypothesis that bone growth is influenced by the cardiovascular changes associated with tail suspension.
Document ID
19900037341
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Roer, Robert D.
(North Carolina Univ. Wilmington, NC, United States)
Dillaman, Richard M.
(North Carolina, University Wilmington, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Journal of Applied Physiology
Volume: 68
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
90A24396
Funding Number(s)
CONTRACT_GRANT: NAG2-391
Distribution Limits
Public
Copyright
Other

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