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Therapeutic effects of antimotion sickness medications on the secondary symptoms of motion sicknessIn addition to nausea and vomiting, motion sickness involves slowing of brain waves, loss of performance, inhibition of gastric motility and the Sopite Syndrome. The therapeutic effects of antimotion sickness drugs on these reactions were evaluated. The subjects were rotated to the M-III end-point of motion sickness. Intramuscular (IM) medications were then administered. Side effects before and after rotation were reported on the Cornell Medical Index. Brain waves were recorded on a Grass Model 6 Electroencephalograph (EEG), and gastric emptying was studied after an oral dose of 1 mCi Technetium 99m DTPA in 10 oz. isotonic saline. An increase in dizziness and drowsiness was reported with placebo after rotation. This was not prevented by IM scopolamine 0.1 mg or ephedrine 25 mg. EEG recordings indicated a slowing of alpha waves with some thea and delta waves from the frontal areas after rotation. IM ephedine and dimenhydrinate counteracted the slowing while 0.3 mg scopolamine had an additive effect. Alterations of performance on the pursuit meter correlated with the brain wave changes. Gastric emptying was restored by IM metoclopramide. Ephedrine IM but not scopolamine is effective for some of the secondary effects of motion sickness after it is established.
Document ID
19900037379
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wood, C. D.
(Louisiana State Univ. Shreveport, LA, United States)
Stewart, J. J.
(Louisiana State Univ. Shreveport, LA, United States)
Wood, M. J.
(Louisiana State Univ. Shreveport, LA, United States)
Manno, J. E.
(Louisiana State Univ. Shreveport, LA, United States)
Manno, B. R.
(Louisiana State University, Medical Center Shreveport, United States)
Date Acquired
August 14, 2013
Publication Date
February 1, 1990
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 61
ISSN: 0095-6562
Subject Category
Aerospace Medicine
Accession Number
90A24434
Funding Number(s)
CONTRACT_GRANT: NAG9-167
Distribution Limits
Public
Copyright
Other

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