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Effect of body weight gain on insulin sensitivity after retirement from exercise trainingThe effect of the body-weight gain after retirement from an exercise-training program on the retained increase in insulin sensitivity elicited by the training was investigated in exercise-trained (ET) rats. Insulin sensitivity was assessed by oral glucose tolerance and insulin suppression tests immediately after training and during retirement. Results show that, compared with sedentary controls, exercise training enhanced insulin-induced glucose uptake, but the enhanced sensitivity was gradually lost with the end of running activity until after seven days of retirement, when it became equal to that of controls. This loss of enhanced sensitivity to insulin was associated with an accelerated gain in body weight beginning one day after the start of retirement. However, those animals that gained weight only at rates similar to those of control rats, retained their enhanced sensitivity to insulin.
Document ID
Document Type
Reprint (Version printed in journal)
Dolkas, Constantine B.
(NASA Ames Research Center Moffett Field, CA, United States)
Rodnick, Kenneth J.
(Stanford University CA, United States)
Mondon, Carl E.
(USVA, Geriatric Research, Education, and Clinical Center Palo Alto, CA, United States)
Date Acquired
August 14, 2013
Publication Date
February 1, 1990
Publication Information
Publication: Journal of Applied Physiology
Volume: 68
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
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