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The origin of polynucleotide-directed protein synthesisIf protein synthesis evolved in an RNA world it was probably preceded by simpler processes by means of which interaction with amino acids conferred selective advantage on replicating RNA molecules. It is suggested that at first the simple attachment of amino acids to the 2'(3') termini of RNA templates favored initiation of replication at the end of the template rather than at internal positions. The second stage in the evolution of protein synthesis would probably have been the association of pairs of charged RNA adaptors in such a way as to favor noncoded formation of peptides. Only after this process had become efficient could coded synthesis have begun.
Document ID
19900040576
Document Type
Reprint (Version printed in journal)
Authors
Orgel, Leslie E. (Salk Institute for Biological Studies San Diego, CA, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Journal of Molecular Evolution
Volume: 29
ISSN: 0022-2844
Subject Category
CHEMISTRY AND MATERIALS (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
CONTRACT_GRANT: NIH-GM-13435-21
Distribution Limits
Public
Copyright
Other