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Age effects on rat hindlimb muscle atrophy during suspension unloadingThe effects of hindlimb unloading on muscle mass and biochemical responses were examined and compared in adult (450-g) and juvenile (200-g) rats after 1, 7, or 14 days of whole-body suspension. Quantitatively and qualitatively the soleus, gastrocnemius, plantaris, and extensor digitorum longus (EDL) muscles of the hindlimb exhibited a differential sensitivity to suspension and weightlessness unloading in both adults and juveniles. The red slow-twitch soleus exhibited the most pronounced atrophy under both conditions, with juvenile responses being greater than adult. In contrast, the fast-twitch EDL hypertrophied during suspension and atrophied during weightlessness, with no significant difference between adults and juveniles. Determination of biochemical parameters (total protein, RNA, and DNA) indicates a less rapid rate of response in adult muscles.
Document ID
19900042542
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Steffen, Joseph M.
(Louisville Univ. KY, United States)
Fell, Ronald D.
(Louisville Univ. KY, United States)
Geoghegan, Thomas E.
(Louisville Univ. KY, United States)
Ringel, Lisa C.
(Louisville Univ. KY, United States)
Musacchia, X. J.
(Louisville, University KY, United States)
Date Acquired
August 14, 2013
Publication Date
March 1, 1990
Publication Information
Publication: Journal of Applied Physiology
Volume: 68
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
90A29597
Funding Number(s)
CONTRACT_GRANT: NASA ORDER A-53745-C
CONTRACT_GRANT: NAG2-386
Distribution Limits
Public
Copyright
Other

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