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Record Details

Record 88 of 547
Age effects on rat hindlimb muscle atrophy during suspension unloading
Author and Affiliation:
Steffen, Joseph M.(Louisville Univ., KY, United States)
Fell, Ronald D.(Louisville Univ., KY, United States)
Geoghegan, Thomas E.(Louisville Univ., KY, United States)
Ringel, Lisa C.(Louisville Univ., KY, United States)
Musacchia, X. J.(Louisville, University, KY, United States)
Abstract: The effects of hindlimb unloading on muscle mass and biochemical responses were examined and compared in adult (450-g) and juvenile (200-g) rats after 1, 7, or 14 days of whole-body suspension. Quantitatively and qualitatively the soleus, gastrocnemius, plantaris, and extensor digitorum longus (EDL) muscles of the hindlimb exhibited a differential sensitivity to suspension and weightlessness unloading in both adults and juveniles. The red slow-twitch soleus exhibited the most pronounced atrophy under both conditions, with juvenile responses being greater than adult. In contrast, the fast-twitch EDL hypertrophied during suspension and atrophied during weightlessness, with no significant difference between adults and juveniles. Determination of biochemical parameters (total protein, RNA, and DNA) indicates a less rapid rate of response in adult muscles.
Publication Date: Mar 01, 1990
Document ID:
19900042542
(Acquired Nov 28, 1995)
Accession Number: 90A29597
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of Applied Physiology (ISSN 0161-7567); 68; 927-931
Publisher Information: United States
Contract/Grant/Task Num: NASA ORDER A-53745-C; NAG2-386
Financial Sponsor: NASA; United States
Organization Source: Louisville Univ.; KY, United States
Description: 5p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AGE FACTOR; ATROPHY; LIMBS (ANATOMY); MUSCULAR STRENGTH; PHYSIOLOGICAL RESPONSES; WEIGHTLESSNESS; RATS; RIBONUCLEIC ACIDS; SUSPENDING (HANGING)
Imprint And Other Notes: Journal of Applied Physiology (ISSN 0161-7567), vol. 68, March 1990, p. 927-931. Research supported by NSF.
Miscellaneous Notes: Research supported by NSF
Availability Source: Other Sources
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