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Intrapericardial denervation - Radial artery blood flow and heart rate responses to LBNPThe effects of intrapericardial denervation on the radial artery blood flow velocity (RABFV) and heart rate (HR) responses to LBNP in rhesus monkeys were investigated by measuring the RABFV transcutaneously by a continuous-wave Doppler ultrasonic flowmeter in order to derive an index of forearm blood flow response to low (0 to -20 mm Hg) and high (0 to -60 mm Hg) ramp exposures during supine LBNP. Four of the eight subjects were subjected to efferent and afferent cardiac denervation. It was found that, during low levels of LBNP, monkeys with cardiac denervation exhibited no cardiopulmonary baroreceptor-mediated change in the RABFV or HR, unlike the intact animals, which showed steady decreases in RABFV during both high- and low-pressure protocols. It is suggested that forearm blood flow and HR responses to low-level LBNP, along with pharmacological challenge, are viable physiological tests for verifying the completeness of atrial and cardiopulmonary baroreceptor denervation.
Document ID
19900049684
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mckeever, Kenneth H.
(NASA Ames Research Center Moffett Field, CA, United States)
Skidmore, Michael G.
(NASA Ames Research Center Moffett Field, CA, United States)
Keil, Lanny C.
(NASA Ames Research Center Moffett Field, CA, United States)
Sandler, Harold
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 14, 2013
Publication Date
May 1, 1990
Publication Information
Publication: Journal of Applied Physiology
Volume: 68
ISSN: 0161-7567
Subject Category
Life Sciences (General)
Accession Number
90A36739
Distribution Limits
Public
Copyright
Other

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