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Template-directed oligomerization of 5-prime-deoxy 5-nucleosideacetic acid derivatives5-prime-deoxy 5-nucleosideacetic acids H-II are isostructural analogs of nucleotides with a carboxylate group in the place of the 5-prime-phosphate group. In this work, their oligomerization in aqueous solution was studied using a water-soluble carbodiimide as the condensing agent in the presence or absence of an appropriate polynucleotide template. Condensation of adenylic acid analogs IIa, IIIa, and Va in the presence of polyuridylic acid were found to be the most efficient reactions. Cyclization of the activated monomers to lactones and the insolubility of the oligomers in aqueous solution were found to be obstacles to the efficient formation of long oligomers.
Document ID
19900061043
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Harada, Kazuo
(Salk Inst. for Biological Studies San Diego, CA, United States)
Orgel, Leslie E.
(Salk Institute for Biological Studies San Diego, CA, United States)
Date Acquired
August 14, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 20
Issue: 2 19
ISSN: 0169-6149
Subject Category
Space Biology
Accession Number
90A48098
Funding Number(s)
CONTRACT_GRANT: NAGW-1660
Distribution Limits
Public
Copyright
Other

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