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Metabolism of Nonessential N15-Labeled Amino Acids and the Measurement of Human Whole-Body Protein Synthesis RatesEight N-15 labeled nonessential amino acids plus (15)NH4Cl were administered over a 10 h period to four healthy adult males using a primed-constant dosage regimen. The amount of N-15 excreted in the urine and the urinary ammonia, hippuric acid, and plasma alanine N-15 enrichments were measured. There was a high degree of consistency across subjects in the ordering of the nine compounds based on the fraction of N-15 excreted (Kendall coefficient of concordance W = 0.83, P is less than 0.01). Protein synthesis rates were calculated from the urinary ammonia plateau enrichment and the cumulative excretion of N-15. Glycine was one of the few amino acids that gave similar values by both methods.
Document ID
19910016269
Acquisition Source
Legacy CDMS
Document Type
Other
Authors
Stein, T. P.
(Medicine and Dentistry Univ. of New Jersey Camden., United States)
Settle, R. G.
(Medicine and Dentistry Univ. of New Jersey Camden., United States)
Albina, J. A.
(Medicine and Dentistry Univ. of New Jersey Camden., United States)
Dempsey, D. T.
(Medicine and Dentistry Univ. of New Jersey Camden., United States)
Melnick, G.
(Pennsylvania Univ. Philadelphia., United States)
Date Acquired
September 6, 2013
Publication Date
May 1, 1991
Publication Information
Publication: NASA. Lyndon B. Johnson Space Center, Spacelab Life Sciences 1: Reprints of Background Life Sciences Publications
Subject Category
Aerospace Medicine
Accession Number
91N25583
Funding Number(s)
CONTRACT_GRANT: USPHS-AM-33431
CONTRACT_GRANT: NAS9-16874
Distribution Limits
Public
Copyright
Public Use Permitted.
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