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X ray sensitivity of diploid skin fibroblasts from patients with Fanconi's anemiaExperiments were performed on Fanconi's anemia and normal human fibroblast cell lines growing in culture in an attempt to correlate cell cycle kinetics with genomic damage and determine their bearing on the mechanism of chromosome aberration induction. FA fibroblasts showed a significantly increased susceptibility to chromosomal breakage by x rays in the G2 phase of the cell cycle. No such response was observed in fibroblasts irradiated in the G0 phase. The observed increases in achromatic lesions and in chromatid deletions in FA cells as compared with normal cells appear to indicate that FA cells are deficient in strand break repair and also possibly in base damage excision repair. Experiments are now in progress to further elucidate the mechanisms involved.
Document ID
19910018758
Document Type
Conference Paper
Authors
Kale, Ranjini (Alabama A & M Univ. Normal, AL, United States)
Date Acquired
September 6, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Alabama A & M Univ., NASA-HBCU Space Science and Engineering Research Forum Proceedings
Subject Category
AEROSPACE MEDICINE
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.