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Human skeletal muscle responses to spaceflight and possible countermeasuresThe current status of knowledge concerning the effects of unweighting skeletal muscle is summarized. The results of both ground-based and space-based animal studies are reviewed which show that there is rapid loss in muscle mass, primarily in slow-twitch muscle, of the rat during unweighting of muscle. There is also a shift in the myosin isoforms with muscles such that slow-twitch muscles take on many of the characteristics of fast-twitch muscles. Ground-based studies in human suggest that programs of electrical stimulation can be developed to simulate normal muscular contractions. Attempts to develop countermeasures to the adverse effects of space travel on muscular functions in humans have not been successful to date.
Document ID
19910025540
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Gollnick, Philip D.
(Washington State University Pullman, United States)
Edgerton, V. Reggie
(California, University Los Angeles, United States)
Saltin, Bengt
(Copenhagen University Denmark)
Date Acquired
August 14, 2013
Publication Date
September 1, 1990
Subject Category
Aerospace Medicine
Report/Patent Number
AIAA PAPER 90-3809
Accession Number
91A10163
Funding Number(s)
CONTRACT_GRANT: NAG9-363
Distribution Limits
Public
Copyright
Other

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