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Nuclear lamins during gametogenesis, fertilization and early developmentThe distribution of lamins (described by Gerace, 1978, as major proteins of nuclear envelope) during gametogenesis, fertilization, and early development was investigated in germ cells of a mouse (Mus musculus), an echinoderm (Lytechinus variegatus), and the surf clam (Spisula solidissima) was investigated in order to determine whether the differences detected could be correlated with differences in the function of cells in these stages of the germ cells. In order to monitor the behavior of lamins, the gametes and embryos were labeled with antibodies to lamins A, C, and B extracted from autoimmune sera of patients with scleroderma and Lupus erythematosus. Results indicated that lamin B could be identified in nuclear envelopes on only those nuclei where chromatin is attached and where RNA synthesis takes place.
Document ID
19910035194
Acquisition Source
Legacy CDMS
Document Type
Conference Proceedings
Authors
Maul, G. G.
(Wistar Institute of Anatomy and Biology Philadelphia, PA, United States)
Schatten, G.
(Florida State University Tallahassee, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1986
Subject Category
Life Sciences (General)
Accession Number
91A19817
Funding Number(s)
CONTRACT_GRANT: NSF PCM-83-15900
CONTRACT_GRANT: NIH-HD-12913
CONTRACT_GRANT: NAG2-340
CONTRACT_GRANT: NIH-GM-21615
CONTRACT_GRANT: NIH-HD-363
CONTRACT_GRANT: NIH-CA-10815
Distribution Limits
Public
Copyright
Other

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