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Metabolic alterations induced in cultured skeletal muscle by stretch-relaxation activityMuscle cells differentiated in vitro are repetitively stretched and relaxed in order to determine the presence of short- and long-term alterations occurring in glucose uptake and lactate efflux that are similar to the metabolic alterations occurring in stimulated organ-cultured muscle and in vivo skeletal muscle during the active state. It is observed that whereas mechanical stimulation increases these metabolic parameters within 4-6 h of starting activity, unstimulated basal rates in control cultures also increase during this period of time, and by 8 h, their rates have reached or exceeded the rates in continuously stimulated cells. Measurements of these parameters in media of different compositions show that activity-induced long-term alterations in the parameters occur independently of growth factors in serium and embryo extracts.
Document ID
19910035327
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hatfaludy, Sophia
(Brown Univ. Providence, RI, United States)
Shansky, Janet
(Brown Univ. Providence, RI, United States)
Vandenburgh, Herman H.
(Brown University; Miriam Hospital, Providence, RI, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1989
Publication Information
Publication: American Journal of Physiology: Cell Physiology
Volume: 25
ISSN: 0363-6143
Subject Category
Life Sciences (General)
Accession Number
91A19950
Funding Number(s)
CONTRACT_GRANT: NIH-AR-36266
CONTRACT_GRANT: NAG2-414
Distribution Limits
Public
Copyright
Other

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