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Oligomerizations of deoxyadenosine bis-phosphates and of their 3-prime-5-prime, 3-prime-3-prime, and 5-prime-5-prime dimers - Effects of a pyrophosphate-linked, poly(T) analogThe effect of a 3-prime-5-prime pyrophosphate-linked oligomer of pTp on oligomerizations of pdAp and of its 3-prime-5-prime, 3-prime-3-prime, and 5-prime-5-prime dimers was investigated, using HPLC to separate the reaction mixtures; peak detection was by absorbance monitoring at 254 nm. It was expected that the dimers would form stable complexes with the template, with the degree of stability depending upon the internal linkage of each dimer. It was found that, although the isomers differ substantially in their oligomerization behavior in the absence of template, the analog-template catalyzes the oligomerization to about the same extent in all three cases.
Document ID
19910044013
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Visscher, J.
(Nijmegen Univ. Netherlands)
Bakker, C. G.
(Nijmegen Univ. Netherlands)
Schwartz, Alan W.
(Nijmegen, Katholieke Universiteit Netherlands)
Date Acquired
August 14, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 20
Issue: 5 19
ISSN: 0169-6149
Subject Category
Space Biology
Accession Number
91A28636
Funding Number(s)
CONTRACT_GRANT: NGR-05-067-001
Distribution Limits
Public
Copyright
Other

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