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Record 66 of 5685
Oligomerizations of deoxyadenosine bis-phosphates and of their 3-prime-5-prime, 3-prime-3-prime, and 5-prime-5-prime dimers - Effects of a pyrophosphate-linked, poly(T) analog
Author and Affiliation:
Visscher, J.(Nijmegen Univ., Netherlands)
Bakker, C. G.(Nijmegen Univ., Netherlands)
Schwartz, Alan W.(Nijmegen, Katholieke Universiteit, Netherlands)
Abstract: The effect of a 3-prime-5-prime pyrophosphate-linked oligomer of pTp on oligomerizations of pdAp and of its 3-prime-5-prime, 3-prime-3-prime, and 5-prime-5-prime dimers was investigated, using HPLC to separate the reaction mixtures; peak detection was by absorbance monitoring at 254 nm. It was expected that the dimers would form stable complexes with the template, with the degree of stability depending upon the internal linkage of each dimer. It was found that, although the isomers differ substantially in their oligomerization behavior in the absence of template, the analog-template catalyzes the oligomerization to about the same extent in all three cases.
Publication Date: Jan 01, 1990
Document ID:
19910044013
(Acquired Nov 28, 1995)
Accession Number: 91A28636
Subject Category: SPACE BIOLOGY
Document Type: Journal Article
Publication Information: Origins of Life and Evolution of the Biosphere (ISSN 0169-6149); 20; 5, 19
Publisher Information: Netherlands
Contract/Grant/Task Num: NGR-05-067-001
Financial Sponsor: NASA; United States
Organization Source: Nijmegen Univ.
Description: 7p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ADENOSINES; OLIGOMERS; POLYNUCLEOTIDES; CATALYSIS; DEOXYRIBONUCLEIC ACID; MAGNESIUM CHLORIDES; MANGANESE COMPOUNDS
Imprint And Other Notes: Origins of Life and Evolution of the Biosphere (ISSN 0169-6149), vol. 20, no. 5, 1990, p. 369-375.
Availability Source: Other Sources
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