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Protein crystal growth aboard the U.S. Space Shuttle flights STS-31 and STS-32Results obtained from the Shuttle flight STS-32 flown in January 1990, and preliminary results from the most recent Shuttle flight, STS-31, flown in April 1990, are presented. Crystals grown in microgravity environment include Canavalin, isocitrate lyase, human serum albumin, and Anti-HPr Fab. It is concluded that about 20 percent of proteins flown exhibit better morphologies or better quality data than their earth-grown counterparts. About 40 percent do not yield crystals at all and the remaining 40 percent yield crystals that are either too small for X-ray analysis or produce data of poorer quality than the best earth-grown crystals.
Document ID
19920038254
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Delucas, Lawrence J.
(Alabama Univ. Birmingham, AL, United States)
Smith, Craig D.
(Alabama, University Birmingham, United States)
Carter, Daniel C.
(Alabama Univ. Birmingham, AL, United States)
Twigg, Pam
(Alabama Univ. Birmingham, AL, United States)
He, Xiao-Min
(Alabama Univ. Birmingham, AL, United States)
Snyder, Robert S.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Weber, Patricia C.
(Alabama Univ. Birmingham, AL, United States)
Schloss, J. V.
(Du Pont de Nemours and Co., Central Research and Development Dept., Wilmington DE, United States)
Einspahr, H. M.
(Alabama Univ. Birmingham, AL, United States)
Clancy, L. L.
(Upjohn Co. Kalamazoo, MI, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Advances in Space Research
Volume: 12
Issue: 1, 19
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
92A20878
Distribution Limits
Public
Copyright
Other

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