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Deoxyribonucleoprotein structure and radiation injury - Cellular radiosensitivity is determined by LET-infinity-dependent DNA damage in hydrated deoxyribonucleoproteins and the extent of its repairUntil recently, OH radicals formed in bulk nuclear water were believed to be the major causes of DNA damage that results in cell death, especially for sparsely ionizing radiations. That hypothesis has now been challenged, if not refuted. Lethal genomic DNA damage is determined mainly by energy deposition in deoxyribonucleoproteins, and their hydration shells, and charge (energy) transfer processes within those structures.
Document ID
19920038261
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Lett, J. T.
(Colorado State Univ. Fort Collins, CO, United States)
Peters, E. L.
(Colorado State University Fort Collins, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Advances in Space Research
Volume: 12
Issue: 3-Feb
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
92A20885
Funding Number(s)
CONTRACT_GRANT: NAG9-10
Distribution Limits
Public
Copyright
Other

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