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Alterations in glucose and protein metabolism in animals subjected to simulated microgravityReduction of physical activity due to disease or environmental restraints, such as total bed rest or exposure to spaceflight, leads to atrophy of skeletal muscle and is frequently accompanied by alterations in food intake and the concentration of metabolic regulatory hormones such as insulin. Hindlimb suspension of laboratory rats, as a model for microgravity, also shows marked atrophy of gravity-dependent muscles along with a reduced gain in body weight. Suspended rats exhibit enhanced sensitivity to insulin-induced glucose uptake when compared with normal control rats and resistance to insulin action when compared with control rats matched similarly for reduced body weight gain. These changes are accompanied by decreased insulin binding and tyrosine kinase activity in soleus but not plantaris muscle, unchanged glucose uptake by perfused hindlimb and decreased sensitivity but not responsiveness to insulin-induced suppression of net proteolysis in hindlimb skeletal muscle. These findings suggest that loss of insulin sensitivity during muscle atrophy is associated with decreased insulin binding and tyrosine kinase activity in atrophied soleus muscle along with decreased sensitivity to the effects of insulin on suppressing net protein breakdown but not on enhancing glucose uptake by perfused hindlimb.
Document ID
19920038274
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Mondon, C. E.
(Veterans Administration Hospital Palo Alto, CA, United States)
Rodnick, K. J.
(Veterans Administration Hospital Palo Alto, CA, United States)
Azhar, S.
(Veterans Administration Hospital Palo Alto, CA, United States)
Reaven, G. M.
(USVA, Medical Center Palo Alto, CA, United States)
Dolkas, C. B.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Advances in Space Research
Volume: 12
Issue: 2-3,
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
92A20898
Distribution Limits
Public
Copyright
Other

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