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Record 6 of 3499
Alterations in glucose and protein metabolism in animals subjected to simulated microgravity
External Online Source: doi:10.1016/0273-1177(92)90105-7
Author and Affiliation:
Mondon, C. E.(Veterans Administration Hospital, Palo Alto, CA, United States)
Rodnick, K. J.(Veterans Administration Hospital, Palo Alto, CA, United States)
Azhar, S.(Veterans Administration Hospital, Palo Alto, CA, United States)
Reaven, G. M.(USVA, Medical Center, Palo Alto, CA, United States)
Dolkas, C. B.(NASA Ames Research Center, Moffett Field, CA, United States)
Abstract: Reduction of physical activity due to disease or environmental restraints, such as total bed rest or exposure to spaceflight, leads to atrophy of skeletal muscle and is frequently accompanied by alterations in food intake and the concentration of metabolic regulatory hormones such as insulin. Hindlimb suspension of laboratory rats, as a model for microgravity, also shows marked atrophy of gravity-dependent muscles along with a reduced gain in body weight. Suspended rats exhibit enhanced sensitivity to insulin-induced glucose uptake when compared with normal control rats and resistance to insulin action when compared with control rats matched similarly for reduced body weight gain. These changes are accompanied by decreased insulin binding and tyrosine kinase activity in soleus but not plantaris muscle, unchanged glucose uptake by perfused hindlimb and decreased sensitivity but not responsiveness to insulin-induced suppression of net proteolysis in hindlimb skeletal muscle. These findings suggest that loss of insulin sensitivity during muscle atrophy is associated with decreased insulin binding and tyrosine kinase activity in atrophied soleus muscle along with decreased sensitivity to the effects of insulin on suppressing net protein breakdown but not on enhancing glucose uptake by perfused hindlimb.
Publication Date: Jan 01, 1992
Document ID:
19920038274
(Acquired Nov 22, 1995)
Accession Number: 92A20898
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Advances in Space Research; (ISSN 0273-1177); 12; 2-3,
Publisher Information: United Kingdom
Financial Sponsor: NASA; United States
Organization Source: Veterans Administration Hospital; Palo Alto, CA, United States
NASA Ames Research Center; Moffett Field, CA, United States
Description: 9p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: GLUCOSE; GRAVITATIONAL EFFECTS; MANNED SPACE FLIGHT; MICROGRAVITY; PROTEIN METABOLISM; ANIMALS; ATROPHY; INSULIN; SUSPENDING (HANGING)
Imprint And Other Notes: (Life sciences and space research XXIV/2/ - Radiation biology; Proceedings of the Topical Meeting of the Interdisciplinary Scientific Commission F /Meetings F3, F4, F5, F6 and F1/ of the COSPAR 28th Plenary Meeting, The Hague, Netherlands, June 25-July 6, 1990. A92-20879 07-51) Advances in Space Research (ISSN 0273-1177), vol. 12, no. 2-3, 1992, p. 169-177.
Availability Source: Other Sources
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