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Fluence-related risk coefficients using the Harderian gland data as an exampleA new concept is introduced for assessing the risk of radiation-induced cancer to space travelers: a fluence-related risk coefficient F (called the risk cross section), which is the risk of a cancer per unit particle fluence for a given particle type. Fs are functions of the LET of the particles in the radiation field and, when integrated over fluence-LET spectra and summed, yield the risk of the endpoint of interest. As an example, tumor prevalence data in mice are used to estimate the probability of the induction of mouse Harderian-gland tumor per year on an extramagnetospheric mission inside an idealized shielding configuration of a spherical 1 g/sq cm hick aluminum shell. Results indicate a yearly tumor prevalence of 0.06 at solar minimum conditions, with 60 percent of this arising from charge components with Z between 10 and 28, and two-thirds of the contribution arising from LET components between 10 and 200 keV/micron.
Document ID
19920038303
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Curtis, S. B.
(California Univ. Berkeley. Lawrence Berkeley Lab, CA, United States)
Powers-Risius, P.
(California Univ. Berkeley. Lawrence Berkeley Lab, CA, United States)
Alpen, E. L.
(Lawrence Berkeley Laboratory Berkeley, CA, United States)
Townsend, L. W.
(California Univ. Berkeley. Lawrence Berkeley Lab, CA, United States)
Wilson, J. W.
(NASA Langley Research Center Hampton, VA, United States)
Fry, R. J. M.
(Oak Ridge National Laboratory TN, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Advances in Space Research
Volume: 12
Issue: 3-Feb
ISSN: 0273-1177
Subject Category
Aerospace Medicine
Accession Number
92A20927
Funding Number(s)
CONTRACT_GRANT: DE-AC03-76SF-00098
CONTRACT_GRANT: DE-AC05-84OR-21400
Distribution Limits
Public
Copyright
Other

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