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Record 23 of 3259
Dexamethasone effects on creatine kinase activity and insulin-like growth factor receptors in cultured muscle cells
External Online Source: doi:10.1002/jcp.1041400103
Author and Affiliation:
Whitson, Peggy A.(NASA Johnson Space Center, Houston, TX, United States)
Stuart, Charles A.(Texas, University, Galveston, United States)
Huls, M. H.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Sams, Clarence F.(NASA Lyndon B. Johnson Space Center, Houston, TX, United States)
Cintron, Nitza M.(NASA Johnson Space Center, Houston, TX, United States)
Abstract: The effect of dexamethasone on the activity of creatine kinase (CK) and the insulin-like growth factor I (IGF-I) binding were investigated using skeletal- and cardiac-muscle-derived cultured cell lines (mouse, C2C12; rat, L6 and H9c2). It was found that, in skeletal muscle cells, dexamethasone treatment during differentiation of skeletal-muscle cells caused dose-dependent increases in CK activity and increases in the degree of myotube formation, whereas cardiac cells (H9c2) exhibited very low CK activity during culture or dexamethasone treatment. Results for IGF-I binding were similar in all three cell lines. The IGF-I binding to dexamethasone-treated cells (50 nM for 24 hr on the day prior to confluence) resulted in an increased number of available binding sites, with no effect on the binding affinities.
Publication Date: Jan 01, 1989
Document ID:
(Acquired Nov 22, 1995)
Accession Number: 92A38108
Document Type: Journal Article
Publication Information: Journal of Cellular Physiology (ISSN 0021-9541); 140; 8-17
Publisher Information: United States
Contract/Grant/Task Num: NAG9-172
Organization Source: NASA Johnson Space Center; Houston, TX, United States
NASA; Washington, DC, United States
Description: 10p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
Imprint And Other Notes: Journal of Cellular Physiology (ISSN 0021-9541), vol. 140, 1989, p. 8-17. Research supported by NASA.
Miscellaneous Notes: Research supported by NASA
Availability Source: Other Sources
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