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Characterization of atrial natriuretic peptide receptors in brain microvessel endothelial cellsIn view of the suggestions by Chabrier et al. (1987) and Steardo and Nathanson (1987) that atrial natriuretic peptide (ANP) may play a role in the fluid homeostasis of the brain, the ANP receptors in primary cultures of bovine brain microvessel endothelian cells were quantitated and characterized. Results of partition binding studies and the effect of cGMP additions indicated the presence of at least two types of ANP receptors, with the majority of the receptors being the nonguanylate cyclase coupled receptors. The presence of at least two ANP receptor types suggests an active role for ANP in regulating brain endothelial cell function.
Document ID
19920055485
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Whitson, Peggy A.
(NASA Johnson Space Center Houston, TX, United States)
Huls, M. H.
(Krug International Houston, TX, United States)
Sams, Clarence F.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Journal of Cellular Physiology
Volume: 146
ISSN: 0021-9541
Subject Category
Life Sciences (General)
Accession Number
92A38109
Distribution Limits
Public
Copyright
Other

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