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Hypergravity signal transduction in HeLa cells with concomitant phosphorylation of proteins immunoprecipitated with anti-microtubule-associated protein antibodiesIt is shown that hypergravity (35g) stimulates the production of inositol 1,4,5-trisphosphate (IP3) and decreases adenosine 3-prime,5-prime-cyclic monophosphate (cAMP) levels in HeLa cells. It is proposed that IP3 and cAMP may act as second messengers in hypergravity signal transduction. Phosphorylation of microtubule-associated proteins in both the detergent-soluble and -insoluble fractions suggests that cytoskeletal structures may be influenced by gravity.
Document ID
19920055492
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kumei, Yasuhiro
(Tokyo Medical and Dental University Japan)
Whitson, Peggy A.
(NASA Johnson Space Center Houston, TX, United States)
Sato, Atsushige
(Tokyo Medical and Dental University Japan)
Cintron, Nitza M.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 15, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Experimental Cell Research
Volume: 192
ISSN: 0014-4827
Subject Category
Life Sciences (General)
Accession Number
92A38116
Distribution Limits
Public
Copyright
Other

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