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Cellular immunity and lymphokine production during spaceflightsResults are presented on changes in cellular immunity and in the production of lymphokine in spacecrews during spaceflights. Measurements were carried out on blood samples collected from 50 cosmonauts before and after spaceflights of different duration, on board Salyut-6, Salyut-7, or Mir. Additional data were obtained from rats flown on board the Cosmos-1667 and Cosmos-1887 biosatellites. The parameters measured included the PHA responsiveness of T lymphocytes, the activity of T-helper cells and of nonspecific T suppressors, the activity of the so-called natural killer lymphocytes, the production of gamma-interferon, and the cell-surface markers. Results showed that the frequency and the extent of changes in the immunologic resistance of subjects depended on the duration of the flight. However, even after the most prolonged (365 days) spaceflight, the changes observed were mostly of a functional character with subsequent rapid return to normal.
Document ID
19920056515
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Konstantinova, I. V.
(Institute of Biomedical Problems Moscow, Russia)
Sonnenfeld, G.
(Louisville, University KY, United States)
Lesniak, A. T.
(Institute of Biomedical Problems Moscow, Russia)
Shaffar, L.
(Institut National de la Sante et de la Recherche Medicale Nice, France)
Mandel, A.
(NASA Ames Research Center Moffett Field, CA, United States)
Rykova, M. P.
(NASA Ames Research Center Moffett Field, CA, United States)
Antropova, E. N.
(Institute of Biomedical Problems Moscow, Russia)
Ferrua, B.
(Institut National de la Sante et de la Recherche Medicale Nice, France)
Date Acquired
August 15, 2013
Publication Date
February 1, 1991
Publication Information
Publication: Physiologist, Supplement
Volume: 34
Issue: 1, Fe
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
92A39139
Distribution Limits
Public
Copyright
Other

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