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Cartilage formation in the CELLS 'double bubble' hardwareThe CELLS experiment scheduled to be flown on the first International Microgravity Laboratory is designed to study the effect of microgravity on the cartilage formation, by measuring parameters of growth in a differentiating cartilage cell culture. This paper investigates the conditions for this experiment by studying cartilage differentiation in the 'bubble exchange' hardware with the 'double bubble' design in which the bubbles are joined by a flange which also overlays the gasket. Four types of double bubbles (or double gas permeable membranes) were tested: injection-molded bubbles 0.01- and 0.005-in. thick, and compression molded bubbles 0.015- and 0.01-in. thick. It was found that double bubble membranes of 0.005- and 0.010-in. thickness supported cartilage differentiation, while the 0.015-in. bubbles did not. It was also found that nodule count, used in this study as a parameter, is not the best measure of the amount of cartilage differentiation.
Document ID
19920056524
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Duke, P. J.
(NASA Ames Research Center Moffett Field, CA, United States)
Arizpe, Jorge
(NASA Ames Research Center Moffett Field, CA, United States)
Montufar-Solis, Dina
(Texas, University Houston, United States)
Date Acquired
August 15, 2013
Publication Date
February 1, 1991
Publication Information
Publication: Physiologist, Supplement
Volume: 34
Issue: 1 Fe
ISSN: 0031-9376
Subject Category
Life Sciences (General)
Accession Number
92A39148
Funding Number(s)
CONTRACT_GRANT: NCC2-423
Distribution Limits
Public
Copyright
Other

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