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Mechanisms of accelerated proteolysis in rat soleus muscle atrophy induced by unweighting or denervationA hypothesis proposed by Tischler and coworkers (Henriksen et al., 1986; Tischler et al., 1990) concerning the mechanisms of atrophy induced by unweighting or denervation was tested using rat soleus muscle from animals subjected to hindlimb suspension and denervation of muscles. The procedure included (1) measuring protein degradation in isolated muscles and testing the effects of lysosome inhibitors, (2) analyzing the lysosome permeability and autophagocytosis, (3) testing the effects of altering calcium-dependent proteolysis, and (4) evaluating in vivo the effects of various agents to determine the physiological significance of the hypothesis. The results obtained suggest that there are major differences between the mechanisms of atrophies caused by unweighting and denervation, though slower protein synthesis is an important feature common for both.
Document ID
19920056566
Document Type
Reprint (Version printed in journal)
Authors
Tischler, Marc E. (NASA Ames Research Center Moffett Field, CA, United States)
Kirby, Christopher (NASA Ames Research Center Moffett Field, CA, United States)
Rosenberg, Sara (NASA Ames Research Center Moffett Field, CA, United States)
Tome, Margaret (NASA Ames Research Center Moffett Field, CA, United States)
Chase, Peter (Arizona, University Tucson, United States)
Date Acquired
August 15, 2013
Publication Date
February 1, 1991
Publication Information
Publication: Physiologist, Supplement
Volume: 34
Issue: 1 Fe
ISSN: 0031-9376
Subject Category
LIFE SCIENCES (GENERAL)
Funding Number(s)
CONTRACT_GRANT: NAG2-384
Distribution Limits
Public
Copyright
Other